2025
D. L. Vasquez, F. Einmüller, I. Latka, K. Kulkarni, N. Pallares-Lupon, M. Constantin, J. Marchant, V. Loyer, S. Bloquet, D. El Hamrani, J. Naulin, W. Drexler, J. Popp, A. Unterhuber, M. Andreana, R. D. Walton, I. W. Schie. Cardiac Microanatomy Imaging Using Forward-viewing Optical Coherence Tomography Endoscope. IEEE Transactions on Biomedical Engineering, 2025.
A. Ramoji, P. Baumbach, O. Ryabchykov, et al. Raman Spectroscopy Can Identify Acute and Persistent Biochemical Changes in Leukocytes From Patients With COVID-19 and Non-COVID-19-Associated Sepsis. Biotechnology Journal 20, no. 9: 20, e70105. 
S. Shiwani, I. Latka, J. Popp, C. Krafft, and I. W. Schie. Rapid Microplastic Detection Using High-Throughput Screening Raman Spectroscopy. ACS Omega
2025 10 (30), 33675-33688
Bali, A., Bitter, T., Kouka, M. et al. Establishment of a clinical workflow for in vivo Raman spectroscopy during head and neck cancer surgery. Sci Rep 15, 24230 (2025).
2024
Latka I, Mogensen K, Knorr F, Kuzucu C, Windirsch F, Sandic D, Popp J, Hermann GG, Schie IW. Raman Spectroscopy for Instant Bladder Tumor Diagnosis: System Development and In Vivo Proof-Of-Principle Study in Accordance with the European Medical Device Regulation (MDR2017/745). Cancers. 2024; 16(18):3238.
Vasquez DL, Kreft C, Latka I, Popp J, Mantke R, Schie IW. Colon Tumor Discrimination Combining Independent Endoscopic Probe-Based Raman Spectroscopy and Optical Coherence Tomography Modalities with Bayes Rule. International Journal of Molecular Sciences. 2024; 25(24):13306.
2022
Yang W, Knorr F, Latka I, Vogt M, Hofmann GO, Popp J, Schie IW. Real-time molecular imaging of near-surface tissue using Raman spectroscopy. Light: Science & Applications. 2022; 11(1):90.
Stiebing C, Post N, Schindler C, Göhrig B, Lux H, Popp J, Heutelbeck A, Schie IW. Revealing the Chemical Composition of Birch Pollen Grains by Raman Spectroscopic Imaging. Int. J. Mol. Sci. 2022;23(9):5112.
Cialla-May D, Krafft C, Rösch P, Deckert-Gaudig T, Frosch T, Jahn IJ, Pahlow S, Stiebing C, Meyer-Zedler T, Bocklitz T, Schie IW, Deckert V, Popp J. Raman Spectroscopy and Imaging in Bioanalytics. Anal Chem. 2022;94(1):86-119.
2021
Schie IW, Placzek F, Knorr F, Cordero E, Wurster LM, Hermann GG, Mogensen K, Hasselager T, Drexler W, Popp J. Morpho-molecular signal correlation between optical coherence tomography and Raman spectroscopy for superior image interpretation and clinical diagnosis. Sci Rep. 2021;11(1):9951.
Vasquez D, Knorr F, Hoffmann F, Ernst G, Marcu L, Schmitt M, Guntinas-Lichius O, Popp J, Schie IW. Multimodal scanning microscope combining optical coherence tomography, Raman spectroscopy and fluorescence lifetime microscopy for mesoscale label-free imaging of tissue. Anal Chem. 2021;93(33):11479-11487 .
Schie I, Stiebing C, Popp J. Looking for a perfect match: multimodal combinations of Raman spectroscopy for biomedical applications. J Biomed Opt. 2021;26(8).
2020
Cordero E, Rüger J, Marti D, Mondol AS, Hasselager T, Morgensen K, Hermann GG, Popp J, Schie IW. Bladder tissue characterization using probe-based Raman spectroscopy: Evaluation of tissue heterogeneity and influence on the model prediction. J Biophotonics. 2020;13(2):e201960025.
Placzek F, Cordero BE, Kretschmer S, Wurster LM, Knorr F, González-Cerdas G, Erkkilä MT, Stein P, Ataman C, Hermann GG, Morgensen K, Hasselager T, Andersen PE, Zappe H, Popp J, Drexler W, Leitgeb RA, Schie IW. Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscopy. Analyst. 2020;145(4):1445-1456.
Miletić M, Aškrabić S, Rüger J, Vasić B, Korićanac L, Mondol AS, Dellith J, Popp J, Schie IW, Dohčević-Mitrović Z. Combined Raman and AFM detection of changes in HeLa cervical cancer cells induced by CeO2 nanoparticles – molecular and morphological perspectives. Analyst. 2020;145(11):3983-3995.
Arend N, Pittner A, Ramoji A, Mondol AS, Dahms M, Rüger J, Kurzai O, Schie IW, Bauer M, Popp J. Detection and Differentiation of Bacterial and Fungal Infection of Neutrophils from Peripheral Blood Using Raman Spectroscopy. Anal Chem. 2020;92(15):10560-10568 .
Korinth F, Mondol AS, Stiebing C, Schie IW, Krafft C, Popp J. New methodology to process shifted excitation Raman difference spectroscopy data: a case study of pollen classification. Sci Rep. 2020;10(1):11215.
Yang W, Knorr F, Popp J, Schie IW. Development and evaluation of a hand-held fiber-optic Raman probe with an integrated autofocus unit. Opt Express. 2020;28(21):30760-30770.
2019
Cherkas A, Mondol AS, Rüger J, Urban N, Popp J, Klotz LO, Schie IW. Label-free molecular mapping and assessment of glycogen in C. elegans. Analyst. 2019;144(7):2367-2374.
Yang W, Mondol AS, Stiebing C, Marcu L, Popp J, Schie IW. Raman ChemLighter: Fiber optic Raman probe imaging in combination with augmented chemical reality. J Biophotonics. 2019;12(7):e201800447.
Rüger J, Mondol AS, Schie IW, Popp J, Krafft C. High-throughput screening Raman microspectroscopy for assessment of drug-induced changes in diatom cells. Analyst. 2019;144(15):4488-4492.
Mondol AS, Töpfer N, Rüger J, Neugebauer U, Popp J, Schie IW. New perspectives for viability studies with high-content analysis Raman spectroscopy (HCA-RS). Sci Rep. 2019;9(1):12653.
Stiebing C, Schie IW, Knorr F, Schmitt M, Keijzer N, Kleemann R, Jahn IJ, Jahn M, Kiliaan AJ, Ginner L. Nonresonant Raman spectroscopy of isolated human retina samples complying with laser safety regulations for in vivo measurements. Neurophotonics. 2019;6(4):41106.
Mondol AS, El-Mashtoly SF, Frick T, Gerwert K, Popp J, Schie IW. High-content screening Raman spectroscopy (HCS-RS) of panitumumab-exposed colorectal cancer cells. Analyst. 2019;144(20):6098-6107.
Mondol AS, Patel MD, Rüger J, Stiebing C,Kleiber A, Henkel T, Popp J, Schie IW. Application of High-Throughput Screening Raman Spectroscopy (HTS-RS) for Label-Free Identification and Molecular Characterization of Pollen. Sensors (Basel). 2019;19(20).
2018
Hassoun M, Rüger J, Kirchberger-Tolstik T, Schie IW, Henkel T, Weber K, Cialla-May D, Krafft C, Popp J. A droplet-based microfluidic chip as a platform for leukemia cell lysate identification using surface-enhanced Raman scattering. Anal Bioanal Chem. 2018;410(3):999-1006.
Schie IW, Rüger J, Mondol AS, Ramoji A, Neugebauer U, Krafft C, Popp J. High-Throughput Screening Raman Spectroscopy Platform for Label-Free Cellomics. Anal Chem. 2018;90(3):2023-2030.
Hassoun M, Köse N, Kiselev R, Kirchberger-Tolstik T, Schie IW, Krafft C, Popp J. Quantitation of acute monocytic leukemia cells spiked in control monocytes using surface-enhanced Raman spectroscopy. Anal Methods. 2018;10(23):2785-2791.
Cordero E, Latka I, Matthäus C, Schie I, Popp J. In-vivo Raman spectroscopy: from basics to applications. J Biomed Opt. 2018;23(7):1-23.
Bovenkamp D, Sentosa R, Rank E, Erkkilä MT, Placzek F, Püls J, Drexler W, Leitgeb RA, Garstka N, Shariat SF, Stiebing C, Schie IW, Popp J, Adreana M, Unterhuber A. Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer. Applied Sciences. 2018;8(12):2371.
2017
Krafft C, Schmitt M, Schie IW, Cialla-May D, Matthäus C, Bocklitz T, Popp J. Label-Free Molecular Imaging of Biological Cells and Tissues by Linear and Nonlinear Raman Spectroscopic Approaches. Angew Chem Int Ed Engl. 2017;56(16):4392-4430.
Hassoun M, Schie IW, Tolstik T, Stanca SE, Krafft C, Popp J. Surface-enhanced Raman spectroscopy of cell lysates mixed with silver nanoparticles for tumor classification. Beilstein Journal of Nanotechnology. 2017;8:1183-1190.
Krafft C, Schmitt M, Schie IW, Cialla-May D, Matthäus C, Bocklitz T, Popp J. Markerfreie molekulare Bildgebung biologischer Zellen und Gewebe durch lineare und nichtlineare Raman-spektroskopische Ansätze. Angew Chem. 2017;129(16):4458-4500.
Cordero E, Korinth F, Stiebing C, Krafft C, Schie IW, Popp J. Evaluation of Shifted Excitation Raman Difference Spectroscopy and Comparison to Computational Background Correction Methods Applied to Biochemical Raman Spectra. Sensors (Basel). 2017;17(8).
Egodage K, Matthäus C, Dochow S, Schie IW, Härdtner C, Hilgendorf I, Popp J. Combination of OCT and Raman spectroscopy for improved characterization of atherosclerotic plaque depositions. Chin Opt Lett. 2017;15(9):90008.
2016
Krafft C, Schie IW, Meyer T, Schmitt M, Popp J. Developments in spontaneous and coherent Raman scattering microscopic imaging for biomedical applications. Chem Soc Rev. 2016;45(7):1819-1849.
Kiselev R, Schie IW, Aškrabić S, Krafft C, Popp J. Design and first applications of a flexible Raman micro-spectroscopic system for biological imaging. BSI. 2016;5(2):115-127.
Schie IW, Kiselev R, Krafft C, Popp J. Rapid acquisition of mean Raman spectra of eukaryotic cells for a robust single cell classification. Analyst. 2016;141(23):6387-6395.
Schie IW, Chan JW. Estimation of spectra sample size for characterizing single cells using micro‐Raman spectroscopy. J Raman Spectrosc. 2016;47(4):384-390.
Schie IW, Krafft C, Popp J. Cell classification with low-resolution Raman spectroscopy (LRRS). J Biophotonics. 2016;9(10):994-1000.
Krafft C, Beleites C, Schie IW, Clement JH, Popp J. Raman-based identification of circulating tumor cells for cancer diagnosis. In: Mahadevan-Jansen A, Petrich W, eds. Biomedical Vibrational Spectroscopy 2016: Advances in Research and Industry. SPIE; 2016:970408.
Rüger J, Unger N, Schie IW, Brunner E, Popp J, Krafft C. Assessment of growth phases of the diatom Ditylum brightwellii by FT-IR and Raman spectroscopy. Algal Research. 2016;19:246-252.
2015
Schie IW, Krafft C, Popp J. Applications of coherent Raman scattering microscopies to clinical and biological studies. Analyst. 2015;140(12):3897-3909.
2014
Schie IW, Alber L, Gryshuk AL, Chan JW. Investigating drug induced changes in single, living lymphocytes based on Raman micro-spectroscopy. Analyst. 2014;139(11):2726-2733.
2013
Schie IW, Huser T. Methods and applications of Raman microspectroscopy to single-cell analysis. Appl Spectrosc. 2013;67(8):813-828.
Schie IW, Nolte L, Pedersen TL, Smith Z, Wu J, Yahiatene I, Newman JW, Huser T. Direct comparison of fatty acid ratios in single cellular lipid droplets as determined by comparative Raman spectroscopy and gas chromatography. Analyst. 2013;138(21):6662-6670.
Adkins Y, Schie IW, Fedor D, Reddy A, Nguyen S, Zhou P, Kelley DS, Wu J. A novel mouse model of nonalcoholic steatohepatitis with significant insulin resistance. Lab Invest. 2013;93(12):1313-1322.
Schie IW, Huser T. Label-free analysis of cellular biochemistry by Raman spectroscopy and microscopy. Compr Physiol. 2013;3(2):941-956.
Jiang L, Schie IW, Qian J, He S, Huser T. Coherent anti-Stokes emission from gold nanorods and its potential for imaging applications. Chemphyschem. 2013;14(9):1951-1955.
2011
Schie IW, Wu J, Weeks T, Zern MA, Rutledge JC, Huser T. Label-free imaging and analysis of the effects of lipolysis products on primary hepatocytes. J Biophotonics. 2011;4(6):425-434.
Weeks T, Schie IW, den Hartigh LJ, Rutledge JC, Huser T. Lipid-cell interactions in human monocytes investigated by doubly-resonant coherent anti-Stokes Raman scattering microscopy. J Biomed Opt. 2011;16(2):21117.
Schie IW, Wu J, Zern M, Rutledge JC, Huser T. Label-free characterization of rapid lipid accumulation in living primary hepatocytes after exposure to lipoprotein lipolysis products. J Biophotonics. 2011;4(6):425.
2010
Weeks T, Schie IW, Wachsmann-Hogiu S, Huser T. Signal generation and Raman-resonant imaging by non-degenerate four-wave mixing under tight focusing conditions. J Biophotonics. 2010;3(3):169-175.
2008
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